Protein Synthesis, part 4
the final chapter


I, being relatively perfect, wish to save copies of all my mRNAs,
and to provide additional copies to my offspring ...

The simplest solution is to list the 'opposite' of the desired mRNA's
5'-end to 3'-end on a DNA molecule

Base pairing
rules
mRNA DNA
A T
G C
U A
C G

DNA molecule in chromosome:

  • double helix effectively "covers" coding DNA
    . . - complement strand hydrogen bonded to coding strand
  • transcription to mRNA
    . . - separate double strand along coding fragment
    . . - transcribe mRNA along coding DNA fragment
  • replication to duplicate DNA
    . . - separate entire DNA strands
    . . . - single-stranded coding DNA
    . . . - single-stranded complement DNA
    . . - replicate strands
    . . . - new complement DNA on old coding DNA
    . . . - new coding DNA on old complement DNA
  • meiosis - fertilization to reproduce



    length of DNA molecule
    protein AAs mRNA DNA
    insulin, human 88 270 b 517 b
    myofibril, rabbit 250 756 b 1003 b

    This shows a surplus of 247 b non-coding DNA for each coding DNA fragment
  • based on data for the rabbit myofibril
  • it is my generalization to add the 247 b surplus to human insulin
    There are now also known to be chemical markers (methyl-groups) on
    . the chromatin at the start (5'-end) of coding DNA
    There is also a large amount of non-coding DNA not accounted for above.

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    © 2004 Prof. LaFrance, Ancilla College