Protein Synthesis, part 2
the sequel


proteins are assembled by ribosomes
which do not know how to recognize AA's
so we need an enzyme-readable mechanism to identify AA's ...

. [aside: barcode tags - computer-readable mechanism to identify products]

RNA tags could be hung on AA's to identify them for transfer [tRNA] to polypeptide

for which we need a Secret Decoder Ring

be the first on your block
to get your
Dr. LaFrance
Secret Decoder Ring


Official
Dr. LaFrance
Secret Decoder Ring
1st
5'-end
2nd 3rd
3'-end
A G U C
A AAA
Phe
AGA
Ser
AUA
Tyr
ACA
Cys
A
AAG
Phe
AGG
Ser
AUG
Tyr
ACG
Cys
G
AAU
Leu
AGU
Ser
AUU
_!_
ACU
_!_
U
AAC
Leu
AGC
Ser
AUC
_!_
ACC
Trp
C
G GAA
Leu
GGA
Pro
GUA
His
GCA
Arg
A
GAG
Leu
GGG
Pro
GUG
His
GCG
Arg
G
GAU
Leu
GGU
Pro
GUU
Gln
GCU
Arg
U
GAC
Leu
GGC
Pro
GUC
Gln
GCC
Arg
C
U UAA
Ile
UGA
Thr
UUA
Asn
UCA
Ser
A
UAG
Ile
UGG
Thr
UUG
Asn
UCG
Ser
G
UAU
Ile
UGU
Thr
UUU
Lys
UCU
Arg
U
UAC
Met
UGC
Thr
UUC
Lys
UCC
Arg
C
C CAA
Val
CGA
Ala
CUA
Asp
CCA
Gly
A
CAG
Val
CGG
Ala
CUG
Asp
CCG
Gly
G
CAU
Val
CGU
Ala
CUU
Glu
CCU
Gly
U
CAC
Val
CGC
Ala
CUC
Glu
CCC
Gly
C


But, ribosomes don't know which AA's should come next in polypeptide,
which is, again, plot material ...



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© 2004 Prof. LaFrance, Ancilla College